The Indianapolis Museum of Art is among the largest general art museums in the U.S., with a collection of 42,000 works that spans the range and scope of art history. Highlights include the Samuel Josefowitz Collection of Gauguin and the School of Pont-Aven; the Holliday Collection of Neo-Impressionism, featuring the work of Georges Seurat and his followers; the largest collection of works by J.M.W. Turner outside of Great Britain; one of the most outstanding collections of Japanese Edo-period paintings in the nation; and more than 2,000 objects in the African art collection. Other important collections include Chinese ceramics, West Asian rugs and contemporary studio glass.

Located in downtown Indianapolis, the Eiteljorg Museum is unique, one of two museums east of the Mississippi with both Native American and Western art.